Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols
نویسندگان
چکیده
A synthetic strategy based on reactions of cyclic imine oxides, namely 2H-imidazole 1-oxides, with thiophenols mediated by acetyl chloride was successfully applied as a convenient tool to obtain series novel azaheterocyclic molecules, including water-soluble hydrochloride forms. Optimized reaction conditions found herein for the nucleophilic substitution hydrogen (SNH) in non-aromatic substrates via “addition-elimination” (SNH AE) scheme enabled 15 arylthiolated 2H-imidazoles be prepared yields up 90%. The developed methodology discloses an original way numerous which are interest field medicinal chemistry and materials science.
منابع مشابه
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ژورنال
عنوان ژورنال: Chemistry
سال: 2023
ISSN: ['2624-8549']
DOI: https://doi.org/10.3390/chemistry5030100